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Prediction of Solubility of Racemic (R/S) (±)-Ibuprofen in n-Heptane, Toluene, Benzene and Ethanol

Sattar Ghader

The solubility of racemic (R/S) (±)-ibuprofen in pure solvents: n-heptane, toluene, benzene and ethanol at range 15°C to 60°C using the regular-solution theory, the UNIFAC model and the UNIQUAC model is predicted and compared with the corresponding experimental values reported in previous study. The results of the ideal solubility show that is negligible in comparison to the molar enthalpy of fusion. There is a good agreement between the experimental solubility data of racemic (R/S) (±)-ibuprofen and the results of UNIQUAC model.