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Preparation and In Vitro Evaluation of Chitosan Based Gastric Floating System of Ranitidine Hydrochloride

Rakesh Pahwa, Vipin Kumar and Kanchan Kohli

The objective of the current study was to prepare and evaluate gastroretentive floating system of ranitidine hydrochloride. The floating beads of ranitidine hydrochloride were prepared by employing ionotropic gelation technique. The designed floating beads were characterized for particle size analysis, percentage yield, entrapment efficiency and in vitro buoyancy profile. Findings demonstrated that all prepared beads containing gas forming agent showed excellent buoyancy profile. Formulated beads remained buoyant even after the buoyancy test period in a simulated gastric fluid (pH 1.2). Furthermore, it was also revealed that the concentration of chitosan influenced the physicochemical characteristics of prepared floating beads.