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Preparation and in vitro evaluation of glipizide loaded poly(D,L-lactide-co-glycolide) nanoparticles for effective management of type II diabetes

Shelesh Jain, Swarnlata Saraf

The aim of this study was to formulate glipizide loaded PLGA nanoparticles as a sustained release carrier with enhanced efficacy. PLGA nanoparticles (PLGA NPs) were prepared by oil-in-water (o/w) emulsion solvent extraction/ evaporation technique with slight modification. The prepared Glipizide NPs demonstrate high drug loading and encapsulation efficiencies. Scanning electron microscope photograph showing spherical and porous morphology of the developed NPs. In-vitro drug release study revealed sustained release of glipizide from the delivery system following the Higuchi (R2= 0.9732) andRitzer Peppas (R2 = 0.9825)model explaining diffusion as well as erosion controlled release. The developed glipizideNPs are suitable for reduction in dosing frequency, decrease in side effects, and improved patient compliance.