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Preparation, Characterization and Biological Studies on Pyridoxylidene-Cephalexin Schiff Base Complexes of Aryltellurium (IV)

Deepak A, Chauhan S, Verma KK and Garg S

A novel Schiff base pyridoxylidene-cephalexin (HPL-CPX) synthesized from pyridoxal and cephalexin, form complexes with aryltellurium (IV) trichlorides and diaryltellurium (IV) dichlorides of the type PL-CPX.ArTeCl2 and PL-CPH.Ar2TeCl (where Ar=p-methoxyphenyl, p-ethoxyphenyl, p-hydroxyphenyl and 3-methyl-4-hydroxyphenyl). They have been characterized by elemental analyses, molar conductance, IR and 1H NMR spectroscopy. The spectral studies predict that the coordination of Schiff base to tellurium in a uninegative bidentate manner with-N, -O donor sites of the azomethine-N and deprotonated phenolic-O to give six membered chelate rings with penta coordinated tellurium centre having Ψ-trigonal bipyamidal geometry. The synthesized ligand, and its aryltellurium complexes was screened for its antimicrobial activity against various bacterial and fungal strains.