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Proteolytic Studies in Liver Homogenate in Presence of Substituted Thiosemicarbazones

Ravinder Kaur, Mamta Singh, Suman Jangra and Neera Raghav

A series of substituted benzaldehyde thiosemicarbazones were synthesized and evaluated their effect on endogenous protein hydrolysis in liver homogenate. The results showed that proteolytic enzyme activity depends on the substitution of benzaldehyde and it was observed that p-substituted thiosemicarbazones exerted maximum inhibition.