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Resolving the benign and themalign isomers of aryl amines by HPLC

PriyaNarayanan, R.Ganeshjeevan,S.Suresh,C.Muralidharan

The present work is related to an improved analysis for aryl amine isomers thereby its more reliable identification. Over 24 aromatic amines were declared as carcinogenic and hence banned for usage in consumer articles based on textile, leather or toys etc. There is a specific official method for screening these aryl amines in consumer articles. But the official protocol could not facilitate the confirmation of exact isomer of aryl amines due to poor chromatographic resolution. This study had targeted this lacuna and involved HPLC exploiting various RP columns and mobile phase conditions to achieve the improved detection of isomers of arylamines. The method successfully separated isomers of about 8 different aryl amines with selectivity of 1 or better and the method is applied to real cases of commercial dye samples.