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Simple and selective spectrophotometric determination of atracurium besylate in pharmaceutical formulations using acidic dyes

P.B.Sudha Lakshmi, C.Rambabu*

Two simple and sensitive extraction spectrophotometricmethods have been developed for the determination of atracuriumbesylate in commercial dosage forms. These methods (A and B) are based on ion-pair complex formation reaction between atracuriumbesylatewith acidic dyes alizarin red S (Method A) & tropaeoline ooo (Method B) in chloroform to give highly colored complex species that absorb maximally at 420 and 480 nm, respectively. BeerÂ’s law was obeyed in the concentration limit of 2.5–9.0 µg/mL for method Aand 1.6–8.0 µg/mL for method B. The proposed methods were found to be rapid, accurate, precise, and sensitive for the determination of atracurium besylate in commercial dosage forms without interferences from common additives. The results of analysis have been validated statistically and by recovery studies.