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Simultaneous determination of biperiden and chlorphenoxamine in various dosage forms by spectrophotometry

F.A.A.Issa, S.M.EL-Helbawy, A.M.Abed EL-Magied

Simple and rapid spectrophotometric procedureswere established for quantization of biperiden hydrochloride (BPN) and chlorphenoxamine hydrochloride (CPA). The procedures are based on the reaction between the examined drugsBPN and CPAand picric acid (I), alizarin (II), bromothymol blue (III) and chlorophenol red (IV) producing ion-associates which can be measured at the optimumwavelength. The optimization of the reaction conditions was investigated. BeerÂ’s law is obeyed in the concentration ranges 7.8–122.9 µgml?1. Themolar absorptivity, Sandell sensitivity are also calculated. The correlation oefficient was ¡Ý0.9998 (n = 4) with a relative standard deviation (R.S.D.) ¡Ü1.35 for four determinations. The methods are successfully applied to determine of BPN and CPA in pharmaceutical formulations.