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Simultaneous determination of cinnarizine and dimenhydrinate in binary mixture using, first derivative of ratio spectra and bivariate spectrophotometric techniques

Nesrine T.Lamie

Two accurate and sensitive spectrophotometric methods have been developed and validated for simultaneous determination of cinnarizine (CINN) and dimenhydrinate (DIM) in binary mixture without previous separation. The first method is based on the first derivative of ratio spectra (1DD) obtained by measurement of the amplitudes at 232.8 and 275.5 nm for cinnarizine and dimenhydrinate, respectively. The second method applies bivariate calibration method using 250 and 276 nm as an optimum pair of wavelength for cinnarizine and dimenhydrinate. The linear ranges are 4–20 and 10–45 ìg/mL for cinnarizine and dimenhydrinate, respectively, for both methods. The proposed methods were found to be simple and sensitive for the routine quality control application of cinnarizine and dimenhydrinate in pharmaceutical dosage form and the results have been statistically compared with a reported method.