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Simultaneous Estimation Of Escitalopram Oxalate And Clonazepam In Tablet Formulation By Ratio Spectra Derivative Spectroscopy

Santosh V.Gandhi, Nilesh D.Dhavale, Vijay Y.Jadhav, Shweta S.Sabnis

A new sensitive, simple, rapid and precise method for simultaneous estimation of escitalopram oxalate and clonazepam in combined tablet dosage form has been developed. The method is based on ratio derivative spectrophotometry. The amplitude in first derivative of the ratio spectra at 246.8nm and 214.4nm (minima) were selected to determine escitalopram oxalate and clonazepam in combined formulation respectively. The method showed good linearity, accuracy and reproducibility. Results of analysis validated statistically and by recovery studies.