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Simultaneous estimation of losartan potassium and ramipril from tablets by first order derivative spectroscopy

Neela M.Bhatia, Rituraj B.Desai, Swapnil D.Jadhav

Losartan Potassiumand Ramipril are used in combination for treatment of hypertension. The present work deals with simple spectrophotometric method development for simultaneous estimation of Losartan Potassium (LOS) andRamipril (RAM) in two component tablet formulation. Themethod employed first order derivative spectroscopy. For determination of sampling wavelength 20 ìg/ml of each of LOS and RAMwere scanned in 200- 400 nmrange and sampling wavelengthswere 234 nmfor LOS were RAM showed zero crossing point and 271 nm for RAM were LOS showed zero crossing point in first order derivative spectroscopy. For this method linearity observed in 10-90 ìg/ml for LOS and 2-18 ìg/ml for RAM. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of method. The method is validated as per ICH guidelines.