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Simultaneous Spectrophotometric Estimation of Ibuprofen and Chlorzoxazone in Tablet Dosage Form

R. K. Nema, Mahesh Verma and Manoj Kumar

Two simple and precise spectrophotometric methods are developed for the simultaneous estimation of ibuprofen (IBU) and chlorzoxazone (CHZ) by using simulataneous equation method. IBU and CHZ show their absorption maxima (max) at 221 nm and 283 nm, respectively. Beer's law is obeyed in the concentration range of 2-10 μg/mL for both the drugs at their absorption maxima. The methods are validated statistically by preparing lab made samples of different concentrations of both the drugs. The results of analysis show that the methods are rapid, precise and accurate for the simultaneous estimation of both the drugs in combined dosage form.