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Solvent-Free Synthesis Of 9-Arylacridine-1,8-Diones In The Melt Reaction

Shu-Xiang Wang, Shao-Bo Guo, Ji-Tai Li

9-Arylacridine-1,8-diones have been prepared in one-pot under solventfree condition. It is a simple, atom efficient and environmentally friendly method. The condensations of aromatic aldehydes, ammonium acetate and 5,5-dimethyl-1,3-cyclohexane-dione (or 1,3-cyclohexanedione) in the absence of solvent at 90oC gave the title compounds in 85%-98% yields.