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Solvent-freeOne-pot SynthesisOf Polyhydropyridopyrimidine Derivatives ViaHantzschCondensationUsing SulphamicAcidCatalyst

Gopal Kakade, Balaji Madje, Madhav Ware, Ravi Balaskar, M.S.Shingare

An efficient Hantzsch condensation of polyhydropyridopyrimidine derivatives was reported via a four-component coupling reaction of aldehydes, barbituric acid, ethyl acetoacetate and ammonium acetate in the presence of H2NSO3H under solvent-free conditions. Operational simplicity, use of a reusable, economically convenient catalyst under solvent-free condition is described in this paper.