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Spectrophotometric and potentiometric determination of the stability constant of pyrazinamide-Fe(III) binary complex

A.M.El kosasy, O.A.A.Ghonim, M.F.Ayada, L.E.Abdel-Fattah

The present study offers valuable comparison of two techniques used for determination of stability constant of coordination complex of Pyrazinamide with Fe (III). The stoichiometry of the complex formation was examined applying the continuous variation (Job plot) method and a 1:1 molar ratio has been identified, at the examined concentrations. Stability constant Kst of the formed complex was determined spectrophotometrically according to the spectral changes of PZA absorbance due to complexation and potentiometrically using the technique adopted by Irving and Rossotti.