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Spectrophotometric determination of esomeprazole in bulk and tablet formulation

Seema A.Gosavi, Girija B.Bhavar, Brijesh K.Sutariya, Nikhil R.Sinkar, Rohit R.Sonawane

Three simple accurate and sensitive UV spectrophotometric methods have been developed for the quantitative estimation of esomeprazole in bulk and its pharmaceutical formulations. In method I, 0.1 N sodium hydroxide was used as solvent. Esomeprazole shows maximum absorbance at 305 nm and obeysBeer-Lambert’s law in the concentration range of 5-30g/mL. Inmethod II, 10% DMF was used as solvent. Esomeprazole shows maximum absorbance at 302 nm and obeys Beer-Lambert’s law in the concentration range of 5-30g/mL. In method III, 20% methanol was used as solvent. Esomeprazole showsmaximumabsorbance at 300 nmand obeys linearity in the concentration range of 4-24g/mL. The methods were validated statistically for accuracy, precision and sensitivity.