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Spectrophotometric determination of metoprolol by chargetransfercomplexation.

M.Suman, C.Narasimha Rao, P.Venkateswarlu

This paper presents a simple, sensitive and accurate spectrophotometric method for the determination of metoprolol tartrate in dosage forms and in biological fluid samples. The method is based on the reaction of the drug as n-electron donorwith the pi-acceptor Folin Reagent (NQS). The obtained charge transfer complex was measured at 469 nm. BeerÂÂÂ’s law is obeyed in the concentration range of 7.6-26.2 µg ml-1with correlation coefficient 0.9995. Molar absorbance, Sandell sensitivity, limit of detection and limit of quantification were calculated. The results obtained by proposed method were statistically validated. This method was successfully evaluated for the estimation of drug in commercially available formulations and in biological fluid samples with good recovery and reproducibility.