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Spectrophotometric Determination Of Metronidazole And Secnidazole In Pharmaceutical Preparations With Alpha Naphtol As A Chromogenic Reagent

N.Saffaj, T.Saffaj, M.Charrouf, B.Ihssane, A.Abourriche, Y.Abboud, A.Bennamara

A rapid and sensitive spectrophotometric method is proposed for determination of metronidazole and secnidazole. The method depends on the reduction of metronidazole and secnidazole molecule with zinc dust and hydrochloric acid flowed by diazotization and coupling with α-naphtol to give red colored chromogens easily measured spectrophotometrically which has λmax= 483 nm. The experimental conditions were optimized and Beer’s law was obyed over the applicable concentration ranges.both techniques were applied successfully to a wide variety of pharmaceutical preparations.