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Spectrophotometric method for the determination of pseudoephedrine in bulk and formulations

Krishnamoorthy Balamurugan, Kannan Gokulakrishnan

Asensitive, extraction, derivatizatation, evaporation and complexation free, direct spectrophphotometric method is developed for the determination of Pseudoephedrine (PE) in bulk drugs and pharmaceutical preparation. The optimumconditions for the analysis of the drug are established. Themethod permits the determination of PE over a concentration range of 2.5 µg/ml - 12.5 µg/ml. Detection and quantification limits are calculated. The obtained results showed good recoveries of 98.5 with relative standard deviation of 0.5. The repeatability and reproducibility of PE in methanol is determined. Precision and accuracy of the developed method is used for recovery study. The proposed method is applicable for the assay of PE investigation in dosage forms and the results are in good agreement.