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Starch sulfuric acid: An alternative, eco-friendly catalyst for Biginelli reaction

Ramin Rezaei, Mohammad Hossein Farjam, Sara Malek, Mohammad Reza Sheikhi

The one-pot multicomponent synthesis of 3,4-dihydropyrimidinone derivativesusingstarch sulfuric acid as an environmentallyfriendly biopolymerbased solid acid catalyst from aldehydes, â-keto esters and urea/thiourea without solvent is described. Compared with classical Biginelli reaction conditions, this new methodhas the advantage of minimizing the cost operational hazards and environmental pollution, good yields, shorter reaction times and simplework-up.