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Studies on acetylpyrimidine: A facil one–pot synthesis of condensed pyrimidines

M.G.Assy, M.H.Sherif, Abd El-Galile E.Amr, Zainab M.R.Mohamed

Cyclo addition of benzal acetophenone to mercaptopyrimidine (1) afforded thiopyranopyrimidine (5). Ethylglycinate (7a) reactedwith chloropyrimidine (6) to produce deazapurine (10) while ethylphenylglycinate (7b,c) yielded pyrrolopyrimidine (9a,b). The synthesis of pyrimidodiazpen (13) was achieved from the condensation reaction between compound (6) and hydrazine derivative (11). The synthesis of pyrimidoquinoline (16), pyridopyrimidine (21), (24) was also described.