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Studies on Effect of Binders on Etoricoxib Tablet Formulations

K. Venugopal and K. P. R. Chowdary

Etoricoxib is a selective COX-2 inhibitor, a potent widely prescribed anti-inflammatory and analgesic drug, belongs to Class II under 'BCS' and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Seven formulations were developed with various binders. The formulations were tested in-vitro drug release and hardness, friability disintegration and other tablet properties. Hardness of the tablets was in the range 5-6.5 Kg/sq.cm in all the batches of tablets except those prepared using methyl cellulose and HPMC as binders. The correlation coefficient (r) value between log percent undissolved and time was in the range 0.974-0.999 with various tablet formulations. Much variation was observed in the dissolution characteristics of tablets prepared with various binders.