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Super critical fluid extract of Angelica gigas Nakai promotes collagen synthesis in human dermal fibroblast

Sang Yo Byun, Dong Myung Kim, Mi Ae Yoo, Young Keun Song

The extract of Angelica gigas Nakai by supercritical CO2 promoted the expression of collagen synthesis-related proteins in human dermal fibroblast. The condition applied for the supercritical fluid extraction was 400 bar and 60C. By the proteome expression profiling, both of type 1(-2) collagen chain precursor and prolyl 4-hydroxylasewere expressed 1.7 times more. The procollagen C-endopeptidase was also increased 1.5 times. Proteome analysis proved that Angelica gigas Nakai promoted proteome synthesis related to skin anti-aging in human dermal fibroblasts.