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Synthesis and Antibacterial Effect of 2-(Benzylthio) Methyl-1h-Benzimidazole Derivatives on Two Bacteria of Medical Interest

Souleymane Coulibaly

This work involved the synthesis of ten (10) novel 2-benzylthiomethyl-1H-benzimidazole derivatives (5a-d) and evaluation of their antibacterial activities. These new compounds were synthesized by reacting the isothiouronium-1H-benzimidazole salts (3a and 3b) with the benzyl halides (4) to ethanol reflux in the presence of a sodium hydroxyde solution. The obtained compounds were characterized by nuclear magnetic resonance 1H, 13C NMR and High-Resolution Mass Spectrometry (HRMS). These compounds were evaluated for antibacterial activity on two bacterial strains, Escherichia coli and Staphylococcus aureus. The results showed that on S. aureus, six compounds (5b, 5d, 5e, 5f, 5g and 5j) were significantly potent with antibacterial activity MIC values ranging from 140 to 320 µg/mL. On the bacterial strain E. coli, five compounds (5b, 5e, 5g, 5h and 5j) showed a significant antibacterial effect with MIC ranging from 140 to 400 µg/mL.