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Synthesis and Biological Activities of Some Schiffa TMS Bases of Sulphamido Coumarin

P. Valentina, K. Ilango, M. G. Rajanandh, R. Vijayan and Ankit Kumar Sitoke

Some new Schiff’s base of methyl sulphamido-7-hydroxy-4-methyl coumarin were synthesized and the anti nociceptive and in vitro anti-inflammatory activities were evaluated. The Mannich reaction between 7-hydroxy-4-methyl coumarin, sulphanilamide and formaldehyde gives 7- hydroxy-4-methyl-8[sulphamidomethyl] coumarin (1). The compound (1) with various aromatic aldehydes gives Schiff’s base (2a-2g). All the synthesized compounds were characterized by spectral analysis. The in vitro anti-inflammatory activity was carried by HRBC membrane stabilization method and the antinociceptive activity was carried by Writhing reflux method and hot plate method. All the compounds shows significant anti-inflammatory and anti-nociceptive activity.