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Synthesis and Characterisation of 7-(1H-Benzimidazol-2-yl)-5-(Substituted Phenyl) Pyrido [2, 3-D] Pyrimidin-4-Amine for their Biological Activity

N. Maheswaran, M. Francis Saleshier, K. Mahalakshmi, V. Suresh Kannan, N. Parthiban and K. Ananda Reddy

A new series of 7-(1H-benzimidazol-2-yl)-5-(substituted phenyl) pyrido [2, 3-d] pyrimidin-4- amine (6a-h) were synthesized by reacting substituted cyanopyridine derivatives with formamide, formic acid and dimethyl formamide under reflux. The title compounds have been characterized by IR, 1H NMR and mass spectral data. The synthesized compounds were evaluated for their qualitative antibacterial and in vitro antioxidant activity by agar diffusion and DPPH methods, respectively. In general, the title compounds have shown mild to moderate antibacterial and antioxidant activity as well.