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Synthesis and characterization of novel polymeric biologically active mixed ligand triazole-3-thiones complexes

S.A.Ibrahim, S.A.El-Gyar, A.Abd El-Sameh, M.A.El-Gahami

A series of novel polymeric mixed ligand Co(II), Ni(II), Cu(II) and Cd(II) complexes[MLL’Cl2]mH2O and[MBHTCl.2H2O]nH2O where M=Co(II), Ni(II),Cu(II), Cd(II);m=0-3; L=4-amino-5-benzyl-4H-1,2,4-triazole-3-thione (ABT), 5-benzyl-4-(benzylidene-amino)-4H-1,2,4-triazole-3-thione (BBT), 5- benzyl-4-[(2-hydroxybenzylidene)-amino]-4H-1,2,4-triazole-3-thione (HBHT) and 5-benzyl-4-[(4-mehtoxy-benzylidene)-amino] -4H-1,2,4-triazole-3-thione (BMT) as a primary ligands and L=1,10-phenanthrolinemono-hydrate (phen) or -bipyridyl (bipy) as secondary ligands have been prepared. The analytical data indicated that the interaction between the binary chelates and the secondary ligands proceeds through either substitution or addition reactions. The structures were determined by elemental analysis, molar conductance, magneticmeasurements, thermal behaviour, infrared and electronic spectral data. The stoichiometry of synthesized complexes is 1:1:1 or 1:1:2 (metal: primary ligand: secondary ligand). Octahedral structurewas proposed for the obtained complexes in which the central metal atom is hexa-coordinated. The lowsolubility of the complexes in common organic solvents with their magneticmoment values indicated their polymeric nature. The biological activity of the binary chelates enhanced significantly upon their interaction with the secondary ligands.