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Synthesis and characterization of some analogues of Febuxostat - An anti-hyperuricemia drug

Venkateswara Rao Vallu, Krunal Girishbhai Desai, Sandip Dhaya Patil, Rajendra Agarwal, Pratap Reddy Padi, Mahesh Reddy Ghanta

Febuxostat is indicated use for the treatment of hyperuricemia and gout. During the process development of Febuxostat, ten process related analogues were observed at a level of 0.1-0.15 area percent. Synthesis and characterization of these analogues and investigation of the root cause of their formation is described.