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Synthesis and conformational analysis of new derivatives of 7-Chloro-1,3-Dihydro-5-Phenyl-2H-1,4-Benzodiazepine-2-One

G.H.Imanzadeh, Z.ArastehFard, Y.Sadra

1,4-benzodiazepine-2-ones and their derivatives are prominent structures inmedicinal chemistry. These biomolecules have wide biological activities and posses therapeutic applications. In this works, we introduce new derivatives of 1,4-benzodiazepine-2-oneswhich are synthesized usingmichael addition reaction of 7-chloro- 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine– 2-ones with fumaric esters that matches with green chemistry protocols. The structures of all products are confirmed by FT-IR, 1H-NMR, 13C-NMR andMASS spectroscopy. Since the stereochemistry of 1,4-benzo diazepine- 2-ones is important, we study the most stable conformer of one of the products as a model for conformational analysis by hyper chem soft ware and semi empirical AM1 program. Also, using the 1H-NMR spectrum, we investigate the produced diastereomers of one of products as a model.