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Synthesis, Antimicrobial and Anti-inflammatory Activities of Some New 2, 4, 6-Trisubstituted Pyrimidines

Y. Rajendra Prasad, P. Venkateswara Rao, P. Ravi Kumar and S. Hema Latha

A variety of 2-amino-4-(substituted phenyl/anthryl)-6-(2'-furyl) pyrimidines (3a-f) were synthesized by reacting 1-(2'-furyl)-3- (substituted phenyl/anthryl)-2-propene-1-ones (2a-f) with guanidine hydrochloride. The required 1-(2'-furyl)-3- (substituted phenyl/anthryl)-2-propene-1-ones (2a-f) were prepared by the condensation of 2-acetyl furan with different aldehydes according to Claisen-Schmidt condensation. All these compounds were characterised by means of their IR, 1H NMR spectroscopic data and microanalyses. The newly synthesized compounds were also evaluated for antimicrobial and anti-inflammatory activities and some of these compounds have shown significant activities.