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Synthesis, Characterization and Antimicrobial Activity of Novel Heterocyclic Compounds

Bhut Dipak Kumar Narsibhai, Diva Mishra, Lochan V. Vyavahare and Arun Singh

2-(5-benzoyl-1H-benzo[d][1,2,3]triazol-1-yl)acetohydrazide (1) undergoes simplistic condensation with various substituted benzaldehyde to afford the subsequent 2-(5-benzoyl-1H-benzo[d] [1,2,3]triazol-1-yl)-N'-arylideneacetohydrazide (2a-h) in excellent yield. Cyclo condensation of compounds (2a-h) with chloro acetyl chloride yields 2-(5-benzoyl-1Hbenzo[ d][1,2,3]triazol-1-yl)-N-(3-chloro-2-oxo-4-arylazetidin-1-yl)acetamide (3a-h). The structures of these compounds were established on basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.