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Synthesis, Characterization and Antimicrobial Study of Copper Complex of 1-Acetyl-5-(4-Nitrophenyl)-3-(2-Thienyl)-2-Pyrazoline

Mamta Ahuja and Ravi Sethi

have only one endocyclic double bond and are basic in nature. A classical synthesis of these compounds involve the base-catalyzed aldol condensation reaction of aromatic ketones and aldehydes to give α, β-unsaturated ketones (chalcones), which undergo a subsequent cyclization reaction with hydrazines affording 2-pyrazolines1. They have found to possess antifungal2-3, anticonvulsant4, antidepressant5, antiinflammatory6, antibacterial7-8, anticancer9, antioxidant10, antiviral11, antiamoebic12 and antituberculosis13-14 activities. Some of these compounds have also analgesic15 activity and COX-2 inhibitor16. The prevalence of pyrazoline core in biological active molecules has stimulated the need for elegant and efficient ways to make these heterocyclic lead. Literature reports reveal that the activity of a ligand can be altered. Several folds by coordination with suitable metal ion17, apparently due to the acceretion in lipophilicity of the metal chelates18. In the present study, we have investigated the interaction of Cu(II) with some newly synthesized pyrazolines. All the prepared compounds were screened for their antimicrobial activities