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Synthesis, Characterization and Antioxidant Study of a Few 3-Substituted 1,2,4-Triazole-5-Thiones and their Derivatives

C. P. Muneer, T. Shalina Begum and P. M. Shafi

A few derivatives of 3-substituted-1H-1,2,4-triazole-5(4H)-thiones were synthesized in good yield, by alkylation and Mannich reaction. The synthesized compounds have been characterized on the basis of IR, NMR and mass spectral data. The free radical scavenging activity of six triazolethiones were evaluated by DPPH method. Specific number of them showed moderate activity and the scavenging activity was found to be proportional to the sample concentration.