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Synthesis, Characterization and Biological Activity of Tetraazamacrocyclic Complexes

Vinod T. Kamble and Shyam N. Ibatte

Novel tetraazamacrocyclic complexes of Cu (II), Co (II), Ni (II) and Zn (II) has been synthesized from the reaction of ethylenediamine/o-phenylenediamine/4-nitro-o-phenylenediamine, with acetylacetone/ acetonyl acetone/dimedone/Meldrums acid and divalent metal ions using solid-supported perchloric acid (HClO4-SiO2) as a catalyst. The complexes were characterized by IR, 1 H NMR, EPR spectra, magnetic moments, conductances, thermal analysis (TGA and DTA), and powder X-ray analysis (XRD). The antimicrobial studies of these complexes against Staphylococcus typhi, Staphylococcus aurieus, Escherichia coli and Bacillus subtilis species by Minimum Inhibitory Concentration (MIC) method revealed that these complexes possess potent antibacterial activity.