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Synthesis, Characterization and Biological Evaluation of Certain New Pyrazole Derivatives

Reddy Rambabu, P. Pavan Kumar, J. Venkateswararao and Jampani Subbarao

A new series of substituted pyrazole derivatives were synthesised by 1,3,4-benzoxazinone with active hydrogen atoms of an amino group by conventional synthetic methods to form quinazolinone nucleus. These are further cyclized to prepare different pyrazoles by the reaction with appropriate cyclising agents like acetyl acetone. All the reactions are monitored by TLC technique and chemical tests as applicable. The structures of these compounds have been established by means of IR, proton NMR, Mass spectral analysis and elemental analysis. The compounds have been evaluated to determine their anti-tubercular profile and also were evaluated for antifungal and antimicrobial activity