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Synthesis, Characterization and Ulcerogenic-Analgesic Profile of Some Amino Acid-Diclofenac Conjugates

M. L. Kori, C. S. Sharma, Kalpesh Gaur, Amit Jaiswal, J. R. Patel, R. K. Nema and V. K. Dixit

Various amino acid conjugates of diclofenac were synthesized by reacting amino acid methyl esters with the carboxylic acid moiety of diclofenac using N, N’-dicyclohexylcarbodiimide as a coupling agent. The synthesized compounds were characterized by physico-chemical and spectral studies like IR and 1H NMR. The compounds synthesized were screened for analgesic and ulcerogenic activity by Acetic acid induced method and pyloric ligation induced ulceration method, respectively. All the compounds exhibited significant analgesic activity as compared to diclofenac sodium with less ulcerogenic activity.