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Synthesis of Diethyl-1, 4-Dihydro-2, 6-Dimethyl-4-[(5-Chloro) Pyrazole)]-3, 5-Pyridinedicarboxylates as Calcium Antagonist

Anil Kumar Teotia, Rakesh Kumar and Ramesh Chandra

By the reaction of 2a-f with ethylacetoacetate and ammonia (or amines) in presence of alcohol resulted in new 1, 4-dihydropyridine derivatives 3a-f having a 5-chloropyrazole ring at 4-position of 1, 4-dihydropyridine ring.