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Synthesis of novel 6âH)-pyrano (2,3-c) pyrrol]-2-Oxo-5â-carboxyethylester

Harshita Sachdeva, Anshu Dandia, Har Lal Singh

Novel spiro indole derivatives incorporating pyranopyrroles (5) have been synthesized by the reaction of 1,3-dihydro-3-carboethoxycyanomethylene- 2H-indol-2-one (3) with 2- pyrrolidone (4) under thermal and microwave irradiation conditions. Compound (3) was synthesized by the knoevenagel condensation of indole-2, 3-dione (1) and ethylcyanoacetate (2). All the synthesized compounds have been characterized by IR, 1HNMR studies and elemental analyses. Few compounds have also been screened for antitubercular, antifungal and herbicidal activities.