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The possible hepatoprotective activity of Eclipta alba whole plant extract against CCl4

Rucha Upadhyay, N.D.Pandey, S.S.Narvi, Bahar Ahmed

The hepatoprotective activity of different extracts of whole plant Eclipta alba was investigated against CCl4 induced hepatic damage inmale albino rat. The extract (500mg/kg) administered for 7 dayswere comparedwith the standard silymarin (Silybon -70, 10 mg/kg,b.w.). The petroleum ether, chloroform and methanol extract have shown significant hepatoprotective activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase(SGOT), serum glutamate pyruvate transaminase(SGPT), alkaline phosphatase (ALP) and serumbilirubin, and elevation in total protein (TP) . These biochemical observations were also supplemented by histopathological examination of the liver sections, where the methanol extract was found to be potent among the three extracts.