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Triazolyl Glycoconjugates and their Impact in Medicinal Chemistry

Somesh S, Madhuri K

Triazoles, especially 1,2,3-Triazoles were known for their wide range of biological activities. Cu(I)-Catalyzed 1,3 dipolar cycloadditions of organic azide and terminal alkyne (click reaction) has been extensively used in adjoining two entirely different building blocks having azide and alkyne functionality thus enabling an easy access of simple to complex molecular architectures containing 1,4-disubstituted triazole skeleton. Carbohydrate-based triazole containing molecules in combination of standard drugs and other biologically relevant molecules are always represented itself as impressive drug candidate which show their effect with increased therapeutic efficacy. Triazole synthesis is also important for developing peptide isostere, the triazolyl components has recently gained momentum chemical biology and drug research. This review highlights the extensive application of triazolyl glycoconjugates with their potential scope in medicinal chemistry.