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Urinary CD4+, CD8+, CXCR3+ T Cells and IL10 Cells in Lupus Nephritis Patients

Zahran FM, El-Haggar MM, Sabea MS and Sayed MM

Among the most promising novel biomarkers are molecules involved in the recruitment of cells into the kidney and molecules reflecting renal inflammation (cytokines). Prominent examples are urinary CXCLmotif and IL10. The aim of the present work is to measure urinary CD4+, CD8+, chemokine receptor (CXCR3+) and interleukine 10 (IL10) in Lupus nephritis patients by flow cytometry in urine sample from50 patients with LN and 22 healthy controls and correlate these urinary biomarkers with histological class, activity index and chronicity index. The results showed significant increase in CD4+, CD4+/CD8+, CXCR3+ and IL10 in urine of LN but significant decrease in CD8+. CXCR3+ is negatively correlated with activity index and chronicity index.