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Utility of Brominating Agent and Methyl Orange for Spectrophotometric Determination of Almotriptan in Pharmaceutical Tablets; Applying of Content Uniformity Measurement

Mahmoud AO*, Mohamed AH and Walid EE

A simple, sensitive, specific, rapid and accurate Spectrophotometric assay was described for detection of almotriptan malate (ALM) in pure and pharmaceutical preparation using in situ generated bromine as oxidizing agent, in acid medium, and methyl orange as chromogenic agent. Almotriptan malate is reacted with known amount of bromine and residual unreacted bromine was detected by reacting with amount of methyl orange then determining absorbance at 509 nm. The content of bromine reacted corresponds to the amount of drug. Beer's law is good through a concentration range of 3- 17 μg/ml. LOD is 0.59 ug/mL and LOQ is 1.78 ug/mL. assay has been satisfactory applied to detection of cited drug in bulk, pharmaceutical preparation and content uniformity measurement. Results have been compared statistically with reference assay.