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Validated Simultaneous Estimation Of Telmisartan And Hydrochlorothiazide In Tablet Dosage Form By RP-HPLC

P.Shanmugasundaram, R.Maheswari, V.Gunasekaran, N.Harikrishnan, M.Vijeyaanandhi, K.S.Syed Ali Abtheen


A validated HPLC method for simultaneous estimation of telmisartan and hydrochlorothiazide in tablet formulations is described. Separation was achieved on a gemini C18 column(4.6mm×25 cm), in isocratic mode, with phosphate buffer(pH 2.5), acetonitrile and tetrahydrofuran(6:3:1v/ v/v) as mobile phase at a flow rate of 1 ml/minute. Quantitation was carried out by the use of UV detector in absorbance mode at 225nm. The retention times of telmisartan and hydrochlorothiazide were found to be 5.612 and 4.23 minutes, respectively. Linearity of detector response for telmisartan and hydrochlorothiazide were found to be from 0.32 to 0.48mg/ml and 0.10 to 0.15mg/ml, respectively. The amounts of drug estimated in the average weight of the tablet were found to be 40.75 and 13.00mg, respectively. The proposed method was validated and was found to be suitable, precise, accurate and reproducible, and can be adopted for routine analysis of telmisartan and hydrochlorothiazide in tablet formulation.


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