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Visible Spectrophotometric Determination of Azithromycin in Pure and Dosage Forms

K. Parameswara Rao and M. C. Rao

Two simple, sensitive selective accurate and economical spectrophotometric methods A and B for the determination of azithromycin in bulk drug and pharmaceutical formulations (tablets) have been described in the present work. Method A is based on the formation of colored ion-association complex between azithromycin and tropaeolineo-oo (TPoo) to yield a color exhibiting absorption maximum at 485 nm and obeying Beer’s law in the concentration range of 5-25 μg/mL. The method B is based on the formation of colored ion-association complex between azithromycin and alizarine Red S (ARS) to yield a colored chromogen exhibiting absorption maximum at 440 nm and obeying Beer’s law in the concentration range of 5-25 μg/mL. The results are compared with those obtained using UV spectrophotometric method in chloroforms at 260 nm.